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*                           wbc.mlxtran                                        *
*                           May 18, 2022 at 04:27:39                           *
*                           Monolix version : 2021R1                           *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
CIRC0_pop   :                         7.52     0.404      5.38
MTT_pop     :                          124       5.7      4.61
SLOPU_pop   :                         33.1      2.32         7
GAMMA_pop   :                        0.242   0.00338       1.4

Standard Deviation of the Random Effects -
omega_CIRC0 :                        0.326    0.0419      12.8
omega_MTT   :                        0.242    0.0381      15.8
omega_SLOPU :                         0.37     0.057      15.4

Error Model Parameters -------------------
prop__err   :                        0.233    0.0206      8.85

Elapsed time (seconds):  1.8e+02
CPU time     (seconds):  4.8e+02
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
              min        Q1    median        Q3       max
CIRC0 :       3.1      6.36      7.77      9.59      13.3
MTT   :      78.6       113       130       140       193
SLOPU :      19.2      28.7      31.6      37.8      61.8
GAMMA :     0.242     0.242     0.242     0.242     0.242

Elapsed time (seconds):      7.1
CPU time     (seconds):       19
Iterations:       80 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
              min        Q1    median        Q3       max
CIRC0 :       3.1      6.33      7.34      9.26      12.9
MTT   :      67.5       110       129       142       194
SLOPU :      19.2      31.1      34.3      41.9      67.4
GAMMA :     0.242     0.242     0.242     0.242     0.242

Elapsed time (seconds):     0.76
CPU time     (seconds):        2

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
  CIRC0_pop         1
    MTT_pop 0.0012272         1
  SLOPU_pop  0.060467  0.096743         1
  GAMMA_pop -0.047601  0.079871  0.049902         1
omega_CIRC0         0         0         0         0         1
  omega_MTT         0         0         0         0 0.0023204         1
omega_SLOPU         0         0         0         0-0.0096587 -0.050258         1
  prop__err         0         0         0         0  -0.11291  -0.13982  -0.11756         1

                               min       max   max/min
Eigen values           :      0.76       1.2       1.6

Elapsed time (seconds):    0.098
CPU time     (seconds):        0

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :         810.04
Akaike Information Criteria               (AIC) :         826.04
Corrected Bayesian Information Criteria  (BICc) :         847.31
Bayesian Information Criteria             (BIC) :         840.49

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

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DATASET INFORMATION
Number of individuals: 45
Number of observations (DV): 176
Number of doses: 51

